According to the California Highway Patrol, the crash happened around 7 p.m. Thursday on Highway 70, about 11 miles south of Oroville.
Investigators say a Honda Civic with four people inside going southbound on Highway 70 drifted into the northbound lane and collided head-on with a Ford Mustang.
The driver and three occupants inside of the Honda were killed. The driver and passenger of the Ford Mustang, identified as Larry and Kathi Grundmann of Oroville, are expected to survive.
Friday morning the Butte County Corner's Office released two of the four names of the people killed, Yer Thao, 48, and Zoua Hang.