The highway reopened near Zinfandel Drive as crews put out the fire that started after the motor home crashed into a tree.
The Sacramento Metropolitan Fire District reports someone has been hospitalized with unknown injuries as a result of the crash.
The flames from the RV scorched nearby trees and a fence.
It is unknown what may have caused the crash and sparked the blaze.
Stay with FOX40 News and FOX40.com for more updates as this story develops.