Eastbound lanes on Highway 50 near Watt Avenue in Sacramento reopened late Monday afternoon following a three-car crash.
Traffic was backed up for miles and lanes were closed for more than an hour.
The California Highway Patrol says an SUV slammed into a CalTrans truck, and a third vehicle hit them. The driver of the SUV was stuck inside and taken to the hospital with serious injuries once freed.
Two other people had minor injuries.