Police say the crash was reported around 2 a.m., near the Central Avenue intersection.
Officers arrived to find two wrecked cars. Both drivers were killed.
Police say witnesses reported one of the drivers, later identified as 28-year-old Francisco Verdugo-Garcia, speeding when he went into oncoming traffic. Investigators did not say if drugs or alcohol were factors in the crash.
"When he passed me doing about 100 miles per hour, I came up to the stoplight and when he blew through the stoplight, that's when he collided with her," witness Joshua Watson said.
Verdugo-Garcia hit the car 65-year-old Hope Granados was driving. Watson says he rushed to Granados' side.
"I knelt down beside her, I held her hand, I prayed with her. I tried to get more response from her. I put my hand over her mouth and I felt that there was a little bit of breath coming," Watson said.
Watson says he hopes Granados' family can find comfort that she wasn't alone in her final moments.
"Their loved one wasn’t alone. Somebody was there with them," he said. "Somebody held their hand and comforted them as best as I could."
It was chaos Watson never thought he would see on his early morning commute -- chaos he says could have easily been avoided.