Crews are battling a 2 alarm blaze that started after a coach bus caught fire.
All lanes on eastbound I-80 in Vallejo, just before the Redwood Parkway exit, are blocked. Drivers are being asked to avoid the area if they can.
Reportedly, the fire has spread to a neighboring structure.
The driver is said to have suffered smoke inhalation. No one else was on the bus at the time, CHP says.
All lanes were opened by a little after 8:30 p.m.