EB I-80 at Nyack has reopened to traffic. #trafficalert
— Caltrans District 3 (@CaltransDist3) April 9, 2017
At least one person sustained major injuries in the crash.
Crews were still clearing the crash at 9:45 p.m., according to Caltrans, and were able to clear one of the lanes.
Those attempting to head east down the highway at the Nyack Shell gas station were held back by Caltrans officials.
Officials have not reported the details of the crash or what led up to the incident.
Stay with FOX40 and FOX40.com for more as this story develops.